Endocrine Abstracts

Introduction: The 2017 WHO Classification of Pituitary Tumors grades silent corticotroph adenomas (SCAs) as high-risk adenomas due to their aggressive clinical behaviour (high probability of recurrence). Nonetheless, studies comparing recurrence rates of SCA with other non-functioning pituitary adenomas (NFPAs) subtypes have provided conflicting results necessitating review of the evidence this recommendation relies on.Aims: To estimate recurrence rates ...

Background: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes, and increased risk of post-natal type 2 diabetes and cardiovascular disease. However, whether GDM increases the risk of developing incident Non-alcoholic Fatty Liver Disease (NAFLD) is unclear and has not been well examined in previous studies. This is important considering the significant health burden of NAFLD and the opportunity to interfere in high risk population in order to red...

Objective: This study investigated the association between ethnicity, birthplace and emotional and psychosexual wellbeing in women with Polycystic Ovary Syndrome (PCOS) in the community.Design: International cross-sectional study.Methods: Women with a self-reported PCOS diagnosis by a healthcare professional were invited to complete an online Blue Morpho questionnaire between September-October 2020 (UK) and May-June 2021 (India). F...

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, with an estimated prevalence of 10-15% worldwide. PCOS can have adverse consequences on the emotional wellbeing of the patient. However, evidence exploring the relationship between PCOS and psychosexual wellbeing, specifically sexual function, and dysmorphic appearance concerns, is largely inconclusive.Aim: A systematic review and meta-analysis were undertaken to assess differ...

BackgroundBenign adrenocortical tumours are found in 3–5% of adults and can be non-functioning (NFAT) or associated with cortisol excess. The latter group divides into patients with clinically overt signs (adrenal Cushing’s syndrome, CS) and patients lacking CS signs (mild autonomous cortisol excess, MACE). The 1 mg-overnight dexamethasone suppression test (DST) further differentiates MACE into MACE-1 (possible MACE; post-DST cortisol 50–1...

Background: The overwhelming majority of incidentally discovered adrenal tumours are benign adrenocortical adenomas. These can be non-functioning (NFAT) or associated with cortisol excess on a spectrum ranging from rare clinically overt adrenal Cushing’s syndrome (CS) to much more prevalent mild autonomous cortisol secretion (MACS) without signs of CS. The 1mg-overnight dexamethasone suppression test (DST) further differentiates MACS-1 (possible MACS; post-DST cortisol 50...